View source for 5ivw


==Human core TFIIH bound to DNA within the PIC==
<SX load='5ivw' size='340' side='right' viewer='molstar' caption='[[5ivw]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ivw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IVW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivw OCA], [https://pdbe.org/5ivw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ivw RCSB], [https://www.ebi.ac.uk/pdbsum/5ivw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivw ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ERCC2_HUMAN ERCC2_HUMAN] Trichothiodystrophy;COFS syndrome;Xeroderma pigmentosum complementation group D. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ERCC2_HUMAN ERCC2_HUMAN] ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.<ref>PMID:10024882</ref> <ref>PMID:15494306</ref> <ref>PMID:20797633</ref> <ref>PMID:8413672</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang J]]
[[Category: He Y]]
[[Category: Inouye C]]
[[Category: Ivanov I]]
[[Category: Nogales E]]
[[Category: Tjian R]]
[[Category: Yan C]]