View source for 4f00


==Crystal structure of the substrate binding domain of E.coli DnaK in complex with an apidaecin fragment from the bumblebee (residues 3 to 11)==
<StructureSection load='4f00' size='340' side='right'caption='[[4f00]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4f00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombus_pascuorum Bombus pascuorum] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F00 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f00 OCA], [https://pdbe.org/4f00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f00 RCSB], [https://www.ebi.ac.uk/pdbsum/4f00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f00 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]

==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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</StructureSection>
[[Category: Bombus pascuorum]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Straeter N]]
[[Category: Zahn M]]