View source for 4drr


==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
<StructureSection load='4drr' size='340' side='right'caption='[[4drr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4drr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drr OCA], [https://pdbe.org/4drr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drr RCSB], [https://www.ebi.ac.uk/pdbsum/4drr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rotavirus sp]]
[[Category: Cortes-Penfield NW]]
[[Category: Crawford SE]]
[[Category: Czako R]]
[[Category: Estes MK]]
[[Category: Hu L]]
[[Category: Le Pendu J]]
[[Category: Prasad BVV]]
[[Category: Smith DF]]