View source for 3v33


==Crystal structure of MCPIP1 conserved domain with zinc-finger motif==
<StructureSection load='3v33' size='340' side='right'caption='[[3v33]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3v33]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V33 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.005&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v33 OCA], [https://pdbe.org/3v33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v33 RCSB], [https://www.ebi.ac.uk/pdbsum/3v33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v33 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZC12A_HUMAN ZC12A_HUMAN] Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.<ref>PMID:16574901</ref> <ref>PMID:18364357</ref> <ref>PMID:22561375</ref> 

==See Also==
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao G]]
[[Category: Li X]]
[[Category: Peng W]]
[[Category: Rao Z]]
[[Category: Sun Y]]
[[Category: Wang X]]
[[Category: Xu J]]
[[Category: Xu Y]]