View source for 3pwe


==Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution==
<StructureSection load='3pwe' size='340' side='right'caption='[[3pwe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PWE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.199&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pwe OCA], [https://pdbe.org/3pwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pwe RCSB], [https://www.ebi.ac.uk/pdbsum/3pwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pwe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.

==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Bloom LB]]
[[Category: Marzahn MR]]
[[Category: McKenna R]]
[[Category: Robbins AH]]