View source for 2mfm


==Solution structure of the C-terminally encoded peptide of the plant parasitic nematode Meloidogyne hapla - CEP11==
<StructureSection load='2mfm' size='340' side='right'caption='[[2mfm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meloidogyne_hapla Meloidogyne hapla]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MFM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HZP:(4S)-4-HYDROXY-L-PROLINE'>HZP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfm OCA], [https://pdbe.org/2mfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mfm RCSB], [https://www.ebi.ac.uk/pdbsum/2mfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mfm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G7K427_MEDTR G7K427_MEDTR] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space.

Solution NMR studies of the plant peptide hormone CEP inform function.,Bobay BG, Digennaro P, Scholl E, Imin N, Djordjevic MA, McK Bird D FEBS Lett. 2013 Dec 11;587(24):3979-85. doi: 10.1016/j.febslet.2013.10.033. Epub , 2013 Nov 5. PMID:24211833<ref>PMID:24211833</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mfm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Meloidogyne hapla]]
[[Category: Bird DM]]
[[Category: Bobay BG]]
[[Category: DiGennaro P]]