View source for 2hxr


==Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism==
<StructureSection load='2hxr' size='340' side='right'caption='[[2hxr]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2hxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxr OCA], [https://pdbe.org/2hxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxr RCSB], [https://www.ebi.ac.uk/pdbsum/2hxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxr ProSAT], [https://www.topsan.org/Proteins/MCSG/2hxr TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYNR_ECOLI CYNR_ECOLI] Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Cuff ME]]
[[Category: Edwards AM]]
[[Category: Evdokimova E]]
[[Category: Joachimiak A]]
[[Category: Kagan O]]
[[Category: Savchenko A]]
[[Category: Singer AU]]