View source for 2ctz


==Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8==
<StructureSection load='2ctz' size='340' side='right'caption='[[2ctz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ctz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ctz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctz OCA], [https://pdbe.org/2ctz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ctz RCSB], [https://www.ebi.ac.uk/pdbsum/2ctz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctz ProSAT], [https://www.topsan.org/Proteins/RSGI/2ctz TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/METY1_THET8 METY1_THET8] Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows low CTT beta-lyase activity and very low CTT gamma-synthase activity.<ref>PMID:11566369</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ctz ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Ebihara A]]
[[Category: Imagawa T]]
[[Category: Kousumi Y]]
[[Category: Kuramitsu S]]
[[Category: Nakagawa N]]
[[Category: Tsuge H]]
[[Category: Utsunomiya H]]
[[Category: Yokoyama S]]