View source for 2clp


==Crystal structure of human aflatoxin B1 aldehyde reductase member 3==
<StructureSection load='2clp' size='340' side='right'caption='[[2clp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2clp]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2clp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clp OCA], [https://pdbe.org/2clp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2clp RCSB], [https://www.ebi.ac.uk/pdbsum/2clp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2clp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARK73_HUMAN ARK73_HUMAN] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<ref>PMID:18416522</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2clp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2clp ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Debreczeni JE]]
[[Category: Edwards A]]
[[Category: Gileadi O]]
[[Category: Guo K]]
[[Category: Johansson C]]
[[Category: Kavanagh K]]
[[Category: Marsden BD]]
[[Category: Oppermann U]]
[[Category: Papagrigoriou E]]
[[Category: Smee C]]
[[Category: Sundstrom M]]
[[Category: Turnbull A]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]