View source for 1tue


==The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular Matchmaker E2==
<StructureSection load='1tue' size='340' side='right'caption='[[1tue]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tue]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TUE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tue OCA], [https://pdbe.org/1tue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tue RCSB], [https://www.ebi.ac.uk/pdbsum/1tue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tue ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE1_HPV18 VE1_HPV18] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tue_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tue ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Regulatory protein E2|Regulatory protein E2]]
*[[Replication protein E1|Replication protein E1]]
__TOC__
</StructureSection>
[[Category: Human papillomavirus type 18]]
[[Category: Large Structures]]
[[Category: Abbate EA]]
[[Category: Berger JM]]
[[Category: Botchan MR]]