View source for 1hsm


==THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA==
<StructureSection load='1hsm' size='340' side='right'caption='[[1hsm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HSM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsm OCA], [https://pdbe.org/1hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hsm RCSB], [https://www.ebi.ac.uk/pdbsum/1hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hsm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMGB1_CRIGR HMGB1_CRIGR] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hsm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hsm ConSurf].
<div style="clear:both"></div>

==See Also==
*[[High mobility group protein|High mobility group protein]]
__TOC__
</StructureSection>
[[Category: Cricetulus griseus]]
[[Category: Large Structures]]
[[Category: Carillo MOM]]
[[Category: Cary PD]]
[[Category: Crane-Robinson C]]
[[Category: Driscoll PC]]
[[Category: Norman DG]]
[[Category: Read CM]]