View source for Taylor Gal4 sandbox 2

[[Image:1d66.png|left|200px]]

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{{STRUCTURE_1d66|  PDB=1d66  |  SCENE=  }} 

===DNA RECOGNITION BY GAL4: STRUCTURE OF A PROTEIN/DNA COMPLEX===


A specific DNA complex of the 65-residue, N-terminal fragment of the yeast transcriptional activator, GAL4, has been analysed at 2.7 A resolution by X-ray crystallography. The protein binds as a dimer to a symmetrical 17-base-pair sequence. A small, <scene name='Taylor_Gal4_sandbox_2/Zn_binding/1'>Zn(2+)-containing domain</scene> recognizes a conserved CCG triplet at each end of the site through direct contacts with the major groove. A short coiled-coil dimerization element imposes 2-fold symmetry. A segment of extended polypeptide chain links the metal-binding module to the dimerization element and specifies the length of the site. The relatively open structure of the complex would allow another protein to bind coordinately with GAL4. 

==About this Structure==
[[1d66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D66 OCA]. 

==See Also==
*[[Hydrogen in macromolecular models]]

==Reference==
<ref group="xtra">PMID:1557122</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Carey, M.]]
[[Category: Harrison, S C.]]
[[Category: Marmorstein, R.]]
[[Category: Ptashne, M.]]
[[Category: Double helix]]
[[Category: Protein-dna complex]]
[[Category: Transcription/dna complex]]