View source for 8oru


==cyclic 2,3-diphosphoglycerate synthetase from the hyperthermophilic archaeon Methanothermus fervidus bound to 2,3-diphosphoglycerate and ADP.==
<StructureSection load='8oru' size='340' side='right'caption='[[8oru]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oru]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermus_fervidus_DSM_2088 Methanothermus fervidus DSM 2088]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ORU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ORU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DG2:(2R)-2,3-DIPHOSPHOGLYCERIC+ACID'>DG2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oru OCA], [https://pdbe.org/8oru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oru RCSB], [https://www.ebi.ac.uk/pdbsum/8oru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oru ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CPGS_METFV CPGS_METFV] Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. It is also able to catalyze the hydrolysis of cDPG but with significant slower rates (8-10 times). May be involved in thermoadaptation.<ref>PMID:2226838</ref> <ref>PMID:9811660</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanothermus fervidus DSM 2088]]
[[Category: De Rose SA]]
[[Category: Isupov M]]