View source for 8iw4


==Cryo-EM structure of the SPE-bound mTAAR9-Gs complex==
<StructureSection load='8iw4' size='340' side='right'caption='[[8iw4]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8iw4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IW4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iw4 OCA], [https://pdbe.org/8iw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iw4 RCSB], [https://www.ebi.ac.uk/pdbsum/8iw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iw4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Guo LL]]
[[Category: Li Q]]
[[Category: Lian S]]
[[Category: Rong NK]]
[[Category: Sun JP]]
[[Category: Xu YF]]
[[Category: Yang F]]
[[Category: Zhang MH]]