View source for 8gsd


==Echovirus3 full particle in complex with 6D10 Fab==
<StructureSection load='8gsd' size='340' side='right'caption='[[8gsd]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gsd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E3 Echovirus E3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GSD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gsd OCA], [https://pdbe.org/8gsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gsd RCSB], [https://www.ebi.ac.uk/pdbsum/8gsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gsd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A060BKX4_9ENTO A0A060BKX4_9ENTO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs.

Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.,Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420<ref>PMID:36366420</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8gsd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Echovirus E3]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Fu W]]
[[Category: Wang X]]