View source for 8dgc


==Avs3 bound to phage PhiV-1 terminase==
<StructureSection load='8dgc' size='340' side='right'caption='[[8dgc]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dgc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_PhiV-1 Escherichia phage PhiV-1] and [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgc OCA], [https://pdbe.org/8dgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgc RCSB], [https://www.ebi.ac.uk/pdbsum/8dgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A7G3WWS0_9CAUD A0A7G3WWS0_9CAUD] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome at a unique and precise dsDNA sequence to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Once the DNA is packaged, the terminase detaches from the portal and gets replaced by the tail to finish maturation of the virion.[HAMAP-Rule:MF_04147]

==See Also==
*[[Terminase 3D Structures|Terminase 3D Structures]]
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</StructureSection>
[[Category: Escherichia phage PhiV-1]]
[[Category: Large Structures]]
[[Category: Salmonella enterica]]
[[Category: Gao L]]
[[Category: Koonin EV]]
[[Category: Macrae RK]]
[[Category: Makarova KS]]
[[Category: Strecker J]]
[[Category: Wilkinson ME]]
[[Category: Zhang F]]