View source for 8cuk


==X-ray Structure of the WD40 domain of HOPS subunit Vps11 from Yeast==
<StructureSection load='8cuk' size='340' side='right'caption='[[8cuk]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cuk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CUK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cuk OCA], [https://pdbe.org/8cuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cuk RCSB], [https://www.ebi.ac.uk/pdbsum/8cuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cuk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PEP5_YEAST PEP5_YEAST] Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. It is required for gluconeogenic growth of yeast. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (PubMed:3062374, PubMed:10978279, PubMed:10944212, PubMed:16601699). Acts as component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase VPS21 (PubMed:17488625). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).<ref>PMID:10944212</ref> <ref>PMID:10978279</ref> <ref>PMID:16601699</ref> <ref>PMID:17488625</ref> <ref>PMID:22570702</ref> <ref>PMID:3062374</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Baker RW]]
[[Category: Hughson FM]]
[[Category: Jeffrey PD]]
[[Category: Port SA]]