View source for 7zu6


==Polyoxidovanadate interaction with proteins: crystal structure of lysozyme bound to tetra-vanadate ion (structure 1)==
<StructureSection load='7zu6' size='340' side='right'caption='[[7zu6]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7zu6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZU6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.183&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=V4O:CYCLO-TETRAMETAVANADATE'>V4O</scene>, <scene name='pdbligand=VVB:bis(oxidanyl)vanadium'>VVB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zu6 OCA], [https://pdbe.org/7zu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zu6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zu6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
High-resolution crystal structures of lysozyme in the presence of the potential drug V(IV) O(acetylacetonato)(2) under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V(IV) to V(V) and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V(4) O(12) ](4-) , which interacts with lysozyme non-covalently, and the unprecedented [V(20) O(54) (NO(3) )](n-) , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.

Stabilization and Binding of [V(4) O(12) ](4-) and Unprecedented [V(20) O(54) (NO(3) )](n-) to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V(IV) O(acetylacetonato)(2).,Ferraro G, Tito G, Sciortino G, Garribba E, Merlino A Angew Chem Int Ed Engl. 2023 Dec 11;62(50):e202310655. doi: , 10.1002/anie.202310655. Epub 2023 Oct 13. PMID:37768728<ref>PMID:37768728</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7zu6" style="background-color:#fffaf0;"></div>

==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Ferraro G]]
[[Category: Merlino A]]
[[Category: Tito G]]