View source for 7sym


==Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII)==
<StructureSection load='7sym' size='340' side='right'caption='[[7sym]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7sym]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SYM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sym OCA], [https://pdbe.org/7sym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sym RCSB], [https://www.ebi.ac.uk/pdbsum/7sym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sym ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G1TLT8_RABIT G1TLT8_RABIT] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.[HAMAP-Rule:MF_03016]

==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Abaeva IS]]
[[Category: Brown ZP]]
[[Category: De S]]
[[Category: Frank J]]
[[Category: Hellen CUT]]
[[Category: Pestova TV]]