View source for 7eq9


==Cryo-EM structure of designed protein nanoparticle TIP60 (Truncated Icosahedral Protein composed of 60-mer fusion proteins)==
<StructureSection load='7eq9' size='340' side='right'caption='[[7eq9]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7eq9]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EQ9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eq9 OCA], [https://pdbe.org/7eq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eq9 RCSB], [https://www.ebi.ac.uk/pdbsum/7eq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eq9 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Supramolecular protein nanoparticles and nanocages have potential in a broad range of applications. Recently, we developed a uniform supramolecular protein nanoparticle, TIP60, symmmetrically self-assembled from fusion proteins of a pentameric Sm-like protein and a dimeric MyoX-coil domain. Herein, we report the icosahedral 60-meric structure of TIP60 solved using single-particle cryo-electron microscopy. Interestingly, the structure revealed 20 regular-triangle-like pores on the surface. TIP60 and its mutants have many modifiable sites on their exterior and interior surfaces. The TIP60 architecture will be useful in the development of biomedical and biochemical nanoparticles/nanocages for future applications.

Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60.,Obata J, Kawakami N, Tsutsumi A, Nasu E, Miyamoto K, Kikkawa M, Arai R Chem Commun (Camb). 2021 Oct 5;57(79):10226-10229. doi: 10.1039/d1cc03114g. PMID:34523636<ref>PMID:34523636</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7eq9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Arai R]]
[[Category: Kawakami N]]
[[Category: Kikkawa M]]
[[Category: Miyamoto K]]
[[Category: Obata J]]
[[Category: Tsutsumi A]]