View source for 7ejh


==Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F and 2-hydroxyisoindoline-1,3-dione complex==
<StructureSection load='7ejh' size='340' side='right'caption='[[7ejh]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ejh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lentilactobacillus_kefiri Lentilactobacillus kefiri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7288393&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J66:2-oxidanylisoindole-1,3-dione'>J66</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ejh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ejh OCA], [https://pdbe.org/7ejh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ejh RCSB], [https://www.ebi.ac.uk/pdbsum/7ejh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ejh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RADH_LENKE RADH_LENKE] NADP-dependent (R)-specific alcohol dehydrogenase (ADH) with a broad substrate specificity, able to catalyze in vitro the stereoselective reduction of several aliphatic and aromatic ketones as well as beta-keto esters to the corresponding enantiomerically pure alcohols.<ref>PMID:26644568</ref> 

==See Also==
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lentilactobacillus kefiri]]
[[Category: Cui J]]
[[Category: Huang X]]
[[Category: Wang B]]
[[Category: Zhao H]]
[[Category: Zhou J]]