View source for 7anw


==hSARM1 NAD+ complex==
<StructureSection load='7anw' size='340' side='right'caption='[[7anw]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7anw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ANW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ANW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7anw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7anw OCA], [https://pdbe.org/7anw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7anw RCSB], [https://www.ebi.ac.uk/pdbsum/7anw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7anw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref> 

==See Also==
*[[SARM1 3D structures|SARM1 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dessau M]]
[[Category: Guez-Haddad J]]
[[Category: Hons M]]
[[Category: Isupov MN]]
[[Category: Khazma T]]
[[Category: Mim C]]
[[Category: Opatowsky Y]]
[[Category: Sporny M]]
[[Category: Yaron A]]
[[Category: Zalk R]]