View source for 7aey


==Salmonella typhimurium neuraminidase in complex with isocarba-DANA.==
<StructureSection load='7aey' size='340' side='right'caption='[[7aey]], [[Resolution|resolution]] 0.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7aey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.919&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=R8T:(3~{S},4~{S},5~{R})-4-acetamido-3-oxidanyl-5-[(1~{S},2~{R})-1,2,3-tris(oxidanyl)propyl]cyclohexane-1-carboxylic+acid'>R8T</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aey OCA], [https://pdbe.org/7aey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aey RCSB], [https://www.ebi.ac.uk/pdbsum/7aey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aey ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANH_SALTY NANH_SALTY] Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections.

==See Also==
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Garman EF]]
[[Category: Kuhn P]]
[[Category: Laver WG]]
[[Category: Pape T]]
[[Category: Salinger MT]]
[[Category: Schneider TR]]
[[Category: Sheldrick GM]]
[[Category: Vasella AT]]
[[Category: Vimr ER]]
[[Category: Vorwerk S]]