View source for 7a0e


==The Crystal Structure of Bovine Thrombin in complex with Hirudin (C6U/C14U) at 1.9 Angstroms Resolution==
<StructureSection load='7a0e' size='340' side='right'caption='[[7a0e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7a0e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A0E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a0e OCA], [https://pdbe.org/7a0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a0e RCSB], [https://www.ebi.ac.uk/pdbsum/7a0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a0e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).

==See Also==
*[[Hirudin 3D structures|Hirudin 3D structures]]
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Hirudo medicinalis]]
[[Category: Large Structures]]
[[Category: Hidmi T]]
[[Category: Khouri L]]
[[Category: Lansky S]]
[[Category: Metanis N]]
[[Category: Mousa R]]
[[Category: Pomyalov S]]
[[Category: Shoham G]]