View source for 6zk8


==Native crystal structure of anaerobic F420H2-Oxidase from Methanothermococcus thermolithotrophicus at 1.8A resolution==
<StructureSection load='6zk8' size='340' side='right'caption='[[6zk8]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6zk8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZK8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zk8 OCA], [https://pdbe.org/6zk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zk8 RCSB], [https://www.ebi.ac.uk/pdbsum/6zk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zk8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A452CSW8_METTL A0A452CSW8_METTL] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
F420H2-oxidase (FprA) catalyses the four-electron reduction of O2 to 2H2O using the reduced form of F420 as electron donor. The hydrophobic O2-channel detected by Kr-derivatization and the concerted movement of a gating loop could contribute to prevent unwanted side-reaction between the catalytic intermediates and solvents, therefore preventing reactive oxygen species formation.

Krypton-derivatization highlights O2-channeling in a four-electron reducing oxidase.,Engilberge S, Wagner T, Carpentier P, Girard E, Shima S Chem Commun (Camb). 2020 Sep 17;56(74):10863-10866. doi: 10.1039/d0cc04557h. PMID:32940290<ref>PMID:32940290</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6zk8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanothermococcus thermolithotrophicus]]
[[Category: Carpentier P]]
[[Category: Engilberge S]]
[[Category: Girard E]]
[[Category: Shima S]]
[[Category: Wagner T]]