View source for 6whb


==MEKK1 TOG domain (548-867)==
<StructureSection load='6whb' size='340' side='right'caption='[[6whb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6whb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WHB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9003205&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6whb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6whb OCA], [https://pdbe.org/6whb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6whb RCSB], [https://www.ebi.ac.uk/pdbsum/6whb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6whb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/M3K1_HUMAN M3K1_HUMAN] 46,XY partial gonadal dysgenesis;46,XY complete gonadal dysgenesis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/M3K1_HUMAN M3K1_HUMAN] Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).<ref>PMID:17761173</ref> <ref>PMID:9808624</ref> 

==See Also==
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Filipcik P]]
[[Category: Mace PD]]