View source for 6w1x


==Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex==
<StructureSection load='6w1x' size='340' side='right'caption='[[6w1x]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6w1x]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_penneri Proteus penneri] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W1X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w1x OCA], [https://pdbe.org/6w1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w1x RCSB], [https://www.ebi.ac.uk/pdbsum/6w1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w1x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSY3_PSEAB CSY3_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref> 

==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Proteus penneri]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Golden SM]]
[[Category: Hirschi M]]
[[Category: Lander G]]
[[Category: Santiago-Frangos A]]
[[Category: Wiedenheft B]]
[[Category: Wilkinson R]]