View source for 6v00


==structure of human KCNQ1-KCNE3-CaM complex==
<SX load='6v00' size='340' side='right' viewer='molstar' caption='[[6v00]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6v00]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Anaplasma_marginale Anaplasma marginale] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V00 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v00 OCA], [https://pdbe.org/6v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v00 RCSB], [https://www.ebi.ac.uk/pdbsum/6v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v00 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN] Brugada syndrome;Hypokalemic periodic paralysis. 
== Function ==
[https://www.uniprot.org/uniprot/X5DSL3_ANAMA X5DSL3_ANAMA] [https://www.uniprot.org/uniprot/KCNE3_HUMAN KCNE3_HUMAN] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.[UniProtKB:Q9JJV7]<ref>PMID:10646604</ref> <ref>PMID:12954870</ref> 

==See Also==
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Anaplasma marginale]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mackinnon R]]
[[Category: Sun J]]