View source for 6smv


==Structure of HPV49 E6 protein in complex with MAML1 LxxLL motif==
<StructureSection load='6smv' size='340' side='right'caption='[[6smv]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6smv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_49 Human papillomavirus type 49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SMV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6smv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6smv OCA], [https://pdbe.org/6smv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6smv RCSB], [https://www.ebi.ac.uk/pdbsum/6smv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6smv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAML1_HUMAN MAML1_HUMAN] Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.<ref>PMID:11101851</ref> <ref>PMID:11390662</ref> <ref>PMID:12050117</ref> <ref>PMID:15546612</ref> <ref>PMID:17317671</ref> [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/VE6_HPV49 VE6_HPV49] Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.[HAMAP-Rule:MF_04006]

==See Also==
*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Homo sapiens]]
[[Category: Human papillomavirus type 49]]
[[Category: Large Structures]]
[[Category: Bonhoure A]]
[[Category: Cousido-Siah A]]
[[Category: Kostmann C]]
[[Category: Mitschler A]]
[[Category: Podjarny A]]
[[Category: Suarez IP]]
[[Category: Trave G]]