View source for 6rjk


==Structure of virulence factor SghA from Agrobacterium tumefaciens==
<StructureSection load='6rjk' size='340' side='right'caption='[[6rjk]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6rjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens_A6 Agrobacterium tumefaciens A6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RJK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.922&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjk OCA], [https://pdbe.org/6rjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rjk RCSB], [https://www.ebi.ac.uk/pdbsum/6rjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2I4PGZ0_RHIRD A0A2I4PGZ0_RHIRD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
It is highly intriguing how bacterial pathogens can quickly shut down energy-costly infection machinery once successful infection is established. This study depicts that mutation of repressor SghR increases the expression of hydrolase SghA in Agrobacterium tumefaciens, which releases plant defense signal salicylic acid (SA) from its storage form SA beta-glucoside (SAG). Addition of SA substantially reduces gene expression of bacterial virulence. Bacterial vir genes and sghA are differentially transcribed at early and later infection stages, respectively. Plant metabolite sucrose is a signal ligand that inactivates SghR and consequently induces sghA expression. Disruption of sghA leads to increased vir expression in planta and enhances tumor formation whereas mutation of sghR decreases vir expression and tumor formation. These results depict a remarkable mechanism by which A. tumefaciens taps on the reserved pool of plant signal SA to reprogram its virulence upon establishment of infection.

Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.,Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 1903695116. doi:, 10.1073/pnas.1903695116. PMID:31604827<ref>PMID:31604827</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6rjk" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Agrobacterium tumefaciens A6]]
[[Category: Large Structures]]
[[Category: Chang CQ]]
[[Category: Gao YG]]
[[Category: Wang C]]
[[Category: Ye FZ]]
[[Category: Zhang LH]]