View source for 6lxu


==Crystal structure of methionine gamma-lyase from Fusobacterium nucleatum==
<StructureSection load='6lxu' size='340' side='right'caption='[[6lxu]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._nucleatum_ATCC_25586 Fusobacterium nucleatum subsp. nucleatum ATCC 25586]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxu OCA], [https://pdbe.org/6lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxu RCSB], [https://www.ebi.ac.uk/pdbsum/6lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEGL_FUSNN MEGL_FUSNN] Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia, and that of L-homocysteine (By similarity). Can also use L-cysteine as substrate, catalyzing its alpha,beta-elimination; this activity seems to only minimally contribute to the production of hydrogen sulfide (H2S) by F.nucleatum in the oral cavity, which is toxic for a large variety of cells in periodontal regions (PubMed:21798982).[UniProtKB:Q8L0X4]<ref>PMID:21798982</ref> 

==See Also==
*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fusobacterium nucleatum subsp. nucleatum ATCC 25586]]
[[Category: Large Structures]]
[[Category: Kezuka Y]]
[[Category: Nonaka T]]
[[Category: Yoshida Y]]