View source for 6jxr


==Structure of human T cell receptor-CD3 complex==
<SX load='6jxr' size='340' side='right' viewer='molstar' caption='[[6jxr]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jxr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JXR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxr OCA], [https://pdbe.org/6jxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jxr RCSB], [https://www.ebi.ac.uk/pdbsum/6jxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxr ProSAT]</span></td></tr>
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== Disease ==
[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[https://omim.org/entry/610163 610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref> 
== Function ==
[https://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
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== Publication Abstract from PubMed ==
The alphabeta T cell receptor (TCR), in association with the CD3gammaepsilon-CD3deltaepsilon-CD3zetazeta signalling hexamer, is the primary determinant of T cell development and activation, and of immune responses to foreign antigens. The mechanism of assembly of the TCR-CD3 complex remains unknown. Here we report a cryo-electron microscopy structure of human TCRalphabeta in complex with the CD3 hexamer at 3.7 A resolution. The structure contains the complete extracellular domains and all the transmembrane helices of TCR-CD3. The octameric TCR-CD3 complex is assembled with 1:1:1:1 stoichiometry of TCRalphabeta:CD3gammaepsilon:CD3deltaepsilon:CD3zetazeta. Assembly of the extracellular domains of TCR-CD3 is mediated by the constant domains and connecting peptides of TCRalphabeta that pack against CD3gammaepsilon-CD3deltaepsilon, forming a trimer-like structure proximal to the plasma membrane. The transmembrane segment of the CD3 complex adopts a barrel-like structure formed by interaction of the two transmembrane helices of CD3zetazeta with those of CD3gammaepsilon and CD3deltaepsilon. Insertion of the transmembrane helices of TCRalphabeta into the barrel-like structure via both hydrophobic and ionic interactions results in transmembrane assembly of the TCR-CD3 complex. Together, our data reveal the structural basis for TCR-CD3 complex assembly, providing clues to TCR triggering and a foundation for rational design of immunotherapies that target the complex.

Structural basis of assembly of the human T cell receptor-CD3 complex.,Dong, Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, Wang Y, Gao N, Huang Z Nature. 2019 Sep;573(7775):546-552. doi: 10.1038/s41586-019-1537-0. Epub 2019 Aug, 28. PMID:31461748<ref>PMID:31461748</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6jxr" style="background-color:#fffaf0;"></div>

==See Also==
*[[CD3 3D structures|CD3 3D structures]]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dong D]]
[[Category: Gao N]]
[[Category: Huang Z]]
[[Category: Li N]]
[[Category: Lin J]]
[[Category: Wang Y]]
[[Category: Xie S]]
[[Category: Zhang B]]
[[Category: Zheng J]]
[[Category: Zheng L]]
[[Category: Zhu Y]]