View source for 6hjl


==Affimer:BclxL==
<StructureSection load='6hjl' size='340' side='right'caption='[[6hjl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6hjl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjl OCA], [http://pdbe.org/6hjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjl RCSB], [http://www.ebi.ac.uk/pdbsum/6hjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjl ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Edwards, T A]]
[[Category: Miles, J A]]
[[Category: Tomlinson, D C]]
[[Category: Trinh, C H]]
[[Category: Wilson, A J]]
[[Category: Affimer]]
[[Category: Protein binding]]