View source for 6enn


==Tryptophan Repressor TrpR from E.coli variant T44L T81M N87G S88Y with Indole-3-acetic acid as ligand==
<StructureSection load='6enn' size='340' side='right'caption='[[6enn]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6enn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ENN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpR, rtrY, b4393, JW4356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6enn OCA], [https://pdbe.org/6enn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6enn RCSB], [https://www.ebi.ac.uk/pdbsum/6enn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6enn ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI]] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. 
__TOC__
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Large Structures]]
[[Category: Herud-Sikimic, O]]
[[Category: Hocker, B]]
[[Category: Juergens, G]]
[[Category: Shanmugaratnam, S]]
[[Category: Stiel, A C]]
[[Category: Ligand binding]]
[[Category: Transcription]]