View source for 6eni


==Tryptophan Repressor TrpR from E.coli variant T44L S88Y with Indole-3-acetic acid as ligand==
<StructureSection load='6eni' size='340' side='right'caption='[[6eni]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6eni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ENI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6ejw|6ejw]], [[6ejz|6ejz]], [[6ekp|6ekp]], [[6enn|6enn]], [[6elb|6elb]], [[6elf|6elf]], [[6elg|6elg]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpR, rtrY, b4393, JW4356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eni OCA], [https://pdbe.org/6eni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eni RCSB], [https://www.ebi.ac.uk/pdbsum/6eni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eni ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI]] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. 
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</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Large Structures]]
[[Category: Herud-Sikimic, O]]
[[Category: Hocker, B]]
[[Category: Juergens, G]]
[[Category: Shanmugaratnam, S]]
[[Category: Stiel, A C]]
[[Category: Ligand binding]]
[[Category: Transcription]]