View source for 6bwo


==LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, apo form==
<StructureSection load='6bwo' size='340' side='right'caption='[[6bwo]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BWO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwo OCA], [https://pdbe.org/6bwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bwo RCSB], [https://www.ebi.ac.uk/pdbsum/6bwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LARC_LACPL LARC_LACPL] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.<ref>PMID:24710389</ref> <ref>PMID:27114550</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Lactiplantibacillus plantarum]]
[[Category: Large Structures]]
[[Category: Desguin B]]
[[Category: Fellner M]]
[[Category: Hausinger RP]]
[[Category: Hu J]]