View source for 6bej


==Crystal structure of manganese superoxide dismutase from Xanthomonas citri==
<StructureSection load='6bej' size='340' side='right'caption='[[6bej]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_citri Xanthomonas citri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BEJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.894&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bej OCA], [https://pdbe.org/6bej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bej RCSB], [https://www.ebi.ac.uk/pdbsum/6bej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bej ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8PJZ1_XANAC Q8PJZ1_XANAC] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
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== Publication Abstract from PubMed ==
Citrus canker is a plant disease caused by the bacteria Xanthomonas citri subsp. citri that affects all domestic varieties of citrus. Some annotated genes from the X. citri subsp. citri genome are assigned to an interesting class named "pathogenicity, virulence and adaptation". Amongst these is sodM, which encodes for the gene product XcSOD, one of four superoxide dismutase homologs predicted from the genome. SODs are widespread enzymes that play roles in the oxidative stress response, catalyzing the degradation of the deleterious superoxide radical. In Xanthomonas, SOD has been associated with pathogenesis as a counter measure against the plant defense response. In this work we initially present the 1.8 A crystal structure of XcSOD, a manganese containing superoxide dismutase from Xanthomonas citri subsp. citri. The structure bears all the hallmarks of a dimeric member of the MnSOD family, including the conserved hydrogen-bonding network residues. Despite the apparent gene redundancy, several attempts to obtain a sodM deletion mutant were unsuccessful, suggesting the encoded protein to be essential for bacterial survival. This intriguing observation led us to extend our structural studies to the remaining three SOD homologs, for which comparative models were built. The models imply that X. citri subsp. citri produces an iron-containing SOD which is unlikely to be catalytically active along with two conventional Cu,ZnSODs. Although the latter are expected to possess catalytic activity, we propose they may not be able to replace XcSOD for reasons such as distinct subcellular compartmentalization or differential gene expression in pathogenicity-inducing conditions.

Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri.,Cabrejos DAL, Alexandrino AV, Pereira CM, Mendonca DC, Pereira HD, Novo-Mansur MTM, Garratt RC, Goto LS PLoS One. 2019 Jan 7;14(1):e0209988. doi: 10.1371/journal.pone.0209988., eCollection 2019. PMID:30615696<ref>PMID:30615696</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6bej" style="background-color:#fffaf0;"></div>

==See Also==
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xanthomonas citri]]
[[Category: Alexandrino AV]]
[[Category: Garratt RC]]
[[Category: Goto LS]]
[[Category: Leonardo DA]]
[[Category: Mendoca DC]]
[[Category: Novo-Mansur MTM]]
[[Category: Pereira CM]]
[[Category: Pereira HM]]