View source for 6adq


==Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis==
<SX load='6adq' size='340' side='right' viewer='molstar' caption='[[6adq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6adq]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_mc2_51 Mycobacterium smegmatis mc2 51]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ADQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ADQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9XX:(2S)-1-(hexadecanoyloxy)propan-2-yl+(10S)-10-methyloctadecanoate'>9XX</scene>, <scene name='pdbligand=9Y0:(2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl+(E)-octadec-9-enoate'>9Y0</scene>, <scene name='pdbligand=9YF:(2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl+(9S)-9-methyloctadecanoate'>9YF</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEA:HEME-A'>HEA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MQ9:MENAQUINONE-9'>MQ9</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_oxidase Cytochrome-c oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.1 1.9.3.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6adq OCA], [http://pdbe.org/6adq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6adq RCSB], [http://www.ebi.ac.uk/pdbsum/6adq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6adq ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/A0QQQ1_MYCS2 A0QQQ1_MYCS2]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000393] [[http://www.uniprot.org/uniprot/A0R056_MYCS2 A0R056_MYCS2]] Part of cytochrome c oxidase, its function is unknown.[PIRNR:PIRNR017385] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report a 3.5-A resolution cryo-EM structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate such that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV via a bridging cytochrome subunit. We observe a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for development of treatments for human tuberculosis.

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.,Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z Science. 2018 Oct 25. pii: science.aat8923. doi: 10.1126/science.aat8923. PMID:30361386<ref>PMID:30361386</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6adq" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cytochrome c oxidase 3D structures|Cytochrome c oxidase 3D structures]]
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Cytochrome-c oxidase]]
[[Category: Large Structures]]
[[Category: Mycobacterium smegmatis mc2 51]]
[[Category: Gao, R G]]
[[Category: Gong, H R]]
[[Category: Ji, W X]]
[[Category: Li, J]]
[[Category: Rao, Z H]]
[[Category: Wang, Q]]
[[Category: Wang, S H]]
[[Category: Xu, A]]
[[Category: Electron transport]]
[[Category: Etc]]
[[Category: Lipoprotein]]
[[Category: Mycobacterium]]
[[Category: Respiratory]]
[[Category: Sod]]
[[Category: Supercomplex]]