View source for 5ujm


==Structure of the active form of human Origin Recognition Complex and its ATPase motor module==
<SX load='5ujm' size='340' side='right' viewer='molstar' caption='[[5ujm]], [[Resolution|resolution]] 18.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ujm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ujm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujm OCA], [https://pdbe.org/5ujm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ujm RCSB], [https://www.ebi.ac.uk/pdbsum/5ujm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Ear-patella-short stature syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
__TOC__
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Elkayam E]]
[[Category: Joshua-Tor L]]
[[Category: Li H]]
[[Category: On K]]
[[Category: Stillman B]]
[[Category: Sun J]]
[[Category: Tocilj A]]
[[Category: Yuan Z]]