View source for 5iy0


==PfMCM N-terminal domain double hexamer==
<StructureSection load='5iy0' size='340' side='right'caption='[[5iy0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iy0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IY0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iy0 OCA], [https://pdbe.org/5iy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iy0 RCSB], [https://www.ebi.ac.uk/pdbsum/5iy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iy0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8U3I4_PYRFU Q8U3I4_PYRFU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the N-terminal domain of the Pyrococcus furiosus minichromosome maintenance (MCM) protein as a double hexamer is described. The MCM complex is a ring-shaped helicase that unwinds DNA at the replication fork of eukaryotes and archaea. Prior to replication initiation, the MCM complex assembles as an inactive double hexamer at specific sites of DNA. The presented structure is highly consistent with previous MCM double-hexamer structures and shows two MCM hexamers with a head-to-head interaction mediated by the N-terminal domain. Minor differences include a diminished head-to-head interaction and a slightly reduced inter-hexamer rotation.

Structure of a double hexamer of the Pyrococcus furiosus minichromosome maintenance protein N-terminal domain.,Meagher M, Enemark EJ Acta Crystallogr F Struct Biol Commun. 2016 Jul 1;72(Pt 7):545-51. doi:, 10.1107/S2053230X1600858X. Epub 2016 Jun 22. PMID:27380371<ref>PMID:27380371</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5iy0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Enemark EJ]]
[[Category: Meagher M]]