View source for 5iwz


==Synaptonemal complex protein==
<StructureSection load='5iwz' size='340' side='right'caption='[[5iwz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IWZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.098&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwz OCA], [https://pdbe.org/5iwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iwz RCSB], [https://www.ebi.ac.uk/pdbsum/5iwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iwz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYCP2_MOUSE SYCP2_MOUSE] Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes (PubMed:16717126). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:16717126). Required for insertion of SYCP3 into synaptonemal complexes (PubMed:16717126). May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.<ref>PMID:11463847</ref> <ref>PMID:16717126</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cao X]]
[[Category: Feng J]]
[[Category: Fu S]]
[[Category: Liu L]]
[[Category: Lu J]]
[[Category: Shen Y]]
[[Category: Wu H]]
[[Category: Yang X]]
[[Category: Zeng M]]