View source for 5iv0


==Crystal structure of Eis from Mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme A==
<StructureSection load='5iv0' size='340' side='right'caption='[[5iv0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IV0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6E9:N-(3-METHOXYPHENYL)-N-METHYL-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE-6-SULFONAMIDE'>6E9</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv0 OCA], [https://pdbe.org/5iv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iv0 RCSB], [https://www.ebi.ac.uk/pdbsum/5iv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EIS_MYCTU EIS_MYCTU] May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.<ref>PMID:10629183</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Gajadeera CS]]
[[Category: Garneau-Tsodikova S]]
[[Category: Hou C]]
[[Category: Tsodikov OV]]