View source for 5gzn


==Structure of neutralizing antibody bound to Zika envelope protein==
<StructureSection load='5gzn' size='340' side='right'caption='[[5gzn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5gzn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzn OCA], [https://pdbe.org/5gzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gzn RCSB], [https://www.ebi.ac.uk/pdbsum/5gzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1B0XTC8_ZIKV A0A1B0XTC8_ZIKV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV. These two antibodies provided postexposure protection to mice in vivo. Structural studies revealed that Z23 and Z3L1 bound to tertiary epitopes in envelope protein domain I, II, or III, indicating potential targets for ZIKV-specific therapy. Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus.,Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, Wong G, Peng R, Liu S, Li J, Li S, Song J, Liu J, He J, Yuan H, Xiong Y, Liao Y, Li J, Yang J, Tong Z, Griffin BD, Bi Y, Liang M, Xu X, Qin C, Cheng G, Zhang X, Wang P, Qiu X, Kobinger G, Shi Y, Yan J, Gao GF Sci Transl Med. 2016 Dec 14;8(369):369ra179. PMID:27974667<ref>PMID:27974667</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5gzn" style="background-color:#fffaf0;"></div>

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zika virus]]
[[Category: Bi Y]]
[[Category: Cheng G]]
[[Category: Dai L]]
[[Category: Gao GF]]
[[Category: Griffin B]]
[[Category: He J]]
[[Category: Kobinger G]]
[[Category: Li J]]
[[Category: Li S]]
[[Category: Liang M]]
[[Category: Liao Y]]
[[Category: Liu J]]
[[Category: Liu S]]
[[Category: Liu X]]
[[Category: Ma T]]
[[Category: Peng R]]
[[Category: Qi J]]
[[Category: Qiu X]]
[[Category: Shi Y]]
[[Category: Song J]]
[[Category: Tong Z]]
[[Category: Wang P]]
[[Category: Wang Q]]
[[Category: Wong G]]
[[Category: Xiong Y]]
[[Category: Xu X]]
[[Category: Yan J]]
[[Category: Yang H]]
[[Category: Yang J]]
[[Category: Yuan H]]