View source for 5grj


==Crystal structure of human PD-L1 with monoclonal antibody avelumab==
<StructureSection load='5grj' size='340' side='right'caption='[[5grj]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5grj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GRJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.206&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5grj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grj OCA], [https://pdbe.org/5grj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grj RCSB], [https://www.ebi.ac.uk/pdbsum/5grj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> 

==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chai Y]]
[[Category: Chen D]]
[[Category: Gao GF]]
[[Category: Gao S]]
[[Category: Liu J]]
[[Category: Liu K]]
[[Category: Lyu J]]
[[Category: Qi J]]
[[Category: Shi Y]]
[[Category: Song H]]
[[Category: Tan S]]
[[Category: Tan W]]
[[Category: Yan J]]
[[Category: Zhang CW-H]]