View source for 5bpv


==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A==
<StructureSection load='5bpv' size='340' side='right'caption='[[5bpv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.952&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [https://pdbe.org/5bpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [https://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Zaire ebolavirus]]
[[Category: Alcaro S]]
[[Category: Bianco G]]
[[Category: Cannas V]]
[[Category: Corona A]]
[[Category: Daino GL]]
[[Category: Distinto S]]
[[Category: Esposito F]]
[[Category: Fadda V]]
[[Category: Maccioni E]]
[[Category: Taylor GL]]
[[Category: Tramontano E]]
[[Category: Zinzula L]]