View source for 5ajl


==Sdsa sulfatase tetragonal==
<StructureSection load='5ajl' size='340' side='right'caption='[[5ajl]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ajl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajl OCA], [https://pdbe.org/5ajl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ajl RCSB], [https://www.ebi.ac.uk/pdbsum/5ajl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LPAKS_PSEAE LPAKS_PSEAE] Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). The hydrolysis of SDS allows the bacterium to use SDS as a sole carbon or sulfur source (PubMed:16684886). In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial tissues (PubMed:31907968). Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) (PubMed:31907968).<ref>PMID:16684886</ref> <ref>PMID:23061549</ref> <ref>PMID:31907968</ref> 

==See Also==
*[[Sulfatase 3D structures|Sulfatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: De la Mora E]]
[[Category: Flores-Hernandez E]]
[[Category: Jakoncic J]]
[[Category: Moreno A]]
[[Category: Sanchez-Puig N]]
[[Category: Stojanoff V]]