View source for 4z6k


==Alcohol dehydrogenase from the antarctic psychrophile Moraxella sp. TAE 123==
<StructureSection load='4z6k' size='340' side='right'caption='[[4z6k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4z6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Moraxella_sp._TAE123 Moraxella sp. TAE123]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z6K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z6k OCA], [https://pdbe.org/4z6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z6k RCSB], [https://www.ebi.ac.uk/pdbsum/4z6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z6k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADH_MORSE ADH_MORSE] Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate. In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase. To a lesser extent, is also able to reduce aldehydes and ketones. Do not catalyze the further oxidation of aldehydes to carboxylic acids. Cannot use NADP(+) instead of NAD(+).<ref>PMID:9660191</ref> 

==See Also==
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Moraxella sp. TAE123]]
[[Category: Bouriotis V]]
[[Category: Papanikolau Y]]
[[Category: Petratos K]]