View source for 4wm8


==Crystal Structure of Human Enterovirus D68==
<StructureSection load='4wm8' size='340' side='right'caption='[[4wm8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterovirus_D68 Enterovirus D68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WM8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wm8 OCA], [https://pdbe.org/4wm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wm8 RCSB], [https://www.ebi.ac.uk/pdbsum/4wm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wm8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9YLJ3_HED68 Q9YLJ3_HED68] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.

Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786<ref>PMID:25554786</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4wm8" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Enterovirus D68]]
[[Category: Large Structures]]
[[Category: Fokine A]]
[[Category: Kuhn RJ]]
[[Category: Liu Y]]
[[Category: Long F]]
[[Category: Meng G]]
[[Category: Rossmann MG]]
[[Category: Sheng J]]