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==1.15A Resolution Structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain==
<StructureSection load='4o06' size='340' side='right'caption='[[4o06]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O06 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o06 OCA], [https://pdbe.org/4o06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o06 RCSB], [https://www.ebi.ac.uk/pdbsum/4o06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o06 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSMD9_YEAST PSMD9_YEAST] Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2, binds to the proteasomal AAA-ATPase subunit Rpt5. The PDZ domain of Nas2 binds to the C-terminal tail of Rpt5; however, it does not require the C-terminus of Rpt5 for binding. Here, the 1.15 A resolution structure of the PDZ domain of Nas2 is reported. This structure will provide a basis for further insights regarding the structure and function of Nas2 in proteasome assembly.

1.15 A resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain.,Singh CR, Lovell S, Mehzabeen N, Chowdhury WQ, Geanes ES, Battaile KP, Roelofs J Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):418-23. doi:, 10.1107/S2053230X14003884. Epub 2014 Mar 25. PMID:24699731<ref>PMID:24699731</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4o06" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Battaile KP]]
[[Category: Chowdhury WQ]]
[[Category: Geanes E]]
[[Category: Lovell S]]
[[Category: Mehzabeen N]]
[[Category: Roelofs J]]
[[Category: Singh CR]]