View source for 4jos


==Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Francisella philomiragia ATCC 25017 (Target NYSGRC-029335)==
<StructureSection load='4jos' size='340' side='right'caption='[[4jos]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_philomiragia_subsp._philomiragia_ATCC_25017 Francisella philomiragia subsp. philomiragia ATCC 25017]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JOS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jos OCA], [https://pdbe.org/4jos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jos RCSB], [https://www.ebi.ac.uk/pdbsum/4jos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jos ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B0TZL4_FRAP2 B0TZL4_FRAP2] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.[SAAS:SAAS00035153]
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</StructureSection>
[[Category: Francisella philomiragia subsp. philomiragia ATCC 25017]]
[[Category: Large Structures]]
[[Category: Almo SC]]
[[Category: Sampathkumar P]]
[[Category: Schramm VL]]